Keith R. McCrae

Dr. Keith R. McCrae stands out as a distinguished figure in the realm of vascular biology, holding esteemed professorships within the Departments of Molecular Medicine and Pathology at the School of Medicine. His expertise is also a vital asset to the Developmental Therapeutics Program at the Case Comprehensive Cancer Center. At the heart of Dr. McCrae's work is a deep commitment to unraveling the intricate workings of vascular function, exploring how these processes unfold in both healthy states and during illness. A significant focus of his pioneering research lies in the antiphospholipid syndrome, investigating its profound implications for the health of our blood vessels.

His investigations venture into the fundamental components that govern vascular health, particularly focusing on high molecular weight kininogen. This molecule is a crucial player in regulating how our blood vessels function, and Dr. McCrae's research meticulously explores the complex ways kininogen influences vascular well-being. His efforts are aimed at uncovering mechanisms that could potentially pave the way for innovative new treatments. Beyond kininogen, his curiosity extends to the study of microparticles – tiny vesicles circulating in the body that are increasingly recognized for their significant roles in vascular diseases and even cancer. He is dedicated to improving how we detect these microparticles and understanding their functional impact on disease processes.

Throughout his career, Dr. McCrae has made substantial contributions that have significantly advanced the scientific understanding of how vascular diseases develop and progress. His findings are widely published in prominent scientific journals, enriching the collective knowledge of the research community. More than just academic contributions, his work carries tangible promise for improving the lives of patients, offering potential pathways to better clinical outcomes for those affected by vascular conditions.

Dr. McCrae's passion for pushing the boundaries of research is beautifully complemented by his genuine dedication to nurturing the next generation of scientists and collaborating with his peers. He actively fosters an environment where ideas can flourish and innovation thrives. His leadership role within the Case Comprehensive Cancer Center further highlights his commitment to ensuring that discoveries made in the lab are effectively translated into practical applications that directly benefit patient care, ultimately striving to enhance health and recovery.